Nicotinamide Adenine Dinucleotide

A naturally occurring critical coenzyme found in every cell of the body, responsible for energy production, mitochondrial health and cellular repair. A review of over 60 peer-reviewed studies shows how by restoring NAD+ you can realign these hallmarks and extend healthy lifespan. Human trials confirm that supplementation can deliver measurable gains in muscle insulin sensitivity, arterial stiffness, aerobic capacity and inflammatory profiles without serious adverse events. 

An age-related drop in NAD+ now ranks among the most reproducible molecular signatures of aging, driving metabolic slowdown, mitochondrial dysfunction, DNA-repair deficits, chronic inflammation, and stem-cell fatigue.


NAD+ supplementation works best in a structured protocol. We offer an 8-week progressive program designed to restore cellular energy support and reach a sustainable maintenance level.

Key Potential Outcomes and Benefits:

  • Energy Metabolism: NAD+ plays a vital role in mitochondrial energy production, helping to reduce fatigue. Subtle boosts in energy are typically seen within 48 hours.
  • Cardiovascular Health: Possible lowering of systolic blood pressure, decreased arterial stiffness, and improved heart function.
  • Cognitive Function: Potential improvements in brain health, with research into neuroprotection against age-related decline, dementia and symptoms from COVID-19 infection.
  • Anti-Aging & Cellular Repair: Supports sirtuins (longevity genes) to improve DNA repair and counteract accelerated aging markers.
  • Metabolic Health: NAD+ precursors can aid in weight management and improve insulin sensitivity.
  • Immune System Support: Reduced levels of proinflammatory markers have been observed, promoting better immune health.
References
[1]

Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2021 Sep 28;150(4 Suppl):41S–48S.

[2]

Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9:1286.

[3]

Hawkins J, Idoine R, Kwon J, Shao A, Dunne E, Hawkins E, Dawson K, Nkrumah-Elie Y. Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen+ IV and NAD+ IV in healthy adults. 2024 Jan 11.

[4]

Saville KM, Clark J, Wilk A, et al. NAD+-mediated regulation of mammalian base excision repair. DNA Repair (Amst). 2020;93:102930.

[5]

Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

[6]

Elhassan YS, Kluckova K, Fletcher RS, et al. Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures. Cell Rep. 2019;28:1717–1728.e6.