What is TB-500?

TB-500 is the synthetic form of Thymosin Beta-4 (Tβ4), a naturally occurring peptide made up of 43 amino acids. Thymosin Beta-4 is found throughout the body and plays an important role in the body’s natural healing process. It is present in blood platelets, wound fluid, and many different tissues.

Scientists first identified Thymosin Beta-4 in the 1960s while studying the thymus gland, an organ that helps regulate the immune system. Since then, researchers have discovered that this peptide is produced throughout the body and is involved in tissue repair, reducing inflammation, and supporting recovery after injury.

When an injury occurs, the body naturally releases Thymosin Beta-4 to help coordinate the healing process. Research suggests it may help new blood vessels form, encourage healthy cells to move to the injured area, and support the repair of damaged tissue. Because TB-500 is a synthetic version of this naturally occurring peptide, researchers have studied it for its potential role in healing muscles, tendons, ligaments, skin, and other tissues.

TB-500 is scheduled for review by the FDA’s Compounding Advisory Committee in July 2026. During that meeting, the committee will review the available scientific evidence and make recommendations regarding whether TB-500 is appropriate for compounding by licensed pharmacies.